Which country are MIS implants from, and who owns them?

MIS Implants Technologies was founded in the summer of 1995 in the town of Shlomi in northern Israel; according to the company's profile, its founders are two brothers, the Peretz brothers. According to a profile published for the company's 25th anniversary, the first implants were made on a single machine, and the first order of 100 implants was sold in November of the same year. Its name, as Dentsply Sirona's acquisition announcement also states, is short for 'Make It Simple'. Between 2005 and 2010 the company grew and moved to a new industrial and technology park close to its old building; in FDA records and in the acquisition announcement its address is given as Bar Lev.

The same profile contains an interesting detail: among the countries where the company won customers within a few years of being founded, it lists Turkey, Spain and Portugal. MIS took part in the International Dental Show in Cologne in 2001, opened a branch in the USA in the years that followed and expanded its distribution through regional hubs. So MIS is not a brand that has only just arrived in Turkey; it has a history of more than twenty years in the country.

The answer to the ownership question is clear in official documents. On 27 June 2016 Dentsply Sirona announced that it had signed a definitive agreement to buy all the shares in MIS. Its 2016 annual report to the US Securities and Exchange Commission (SEC) states that the acquisition was completed in September 2016. In the list of subsidiaries in the 2025 annual report, filed in February 2026, 'MIS Implants Technologies Ltd. (Israel)' still appears. In the MIS C1, Seven, M4 and Lance+ submissions cleared by the FDA in 2025, the applicant is also Dentsply Sirona directly.

So the question of which country it is from has a two-layered answer. The product's origin and manufacturing address are in Israel; its owner is the US-based Dentsply Sirona. Dentsply Sirona also owns the implant systems called ANKYLOS, Astra Tech and XIVE; in the acquisition announcement it described MIS as a strong brand in the 'value segment' of the market, that is, its more affordably priced part, and wrote that its products were sold in more than 65 countries. This positioning is similar to Neodent's place within the Straumann Group: inside the same group, at a different price level from the group's premium brand.

MIS is not a single implant but a family. According to Dentsply Sirona's announcement, the V3 line was launched in June 2015 at the EuroPerio8 congress. FDA records show systems that are separate from one another: 'V3 Conical Connection' in 2017, 'C1 Narrow Platform Conical Connection' also in 2017, 'MIS Internal Hex Dental Implant System' in 2018, and C1, Seven, M4, Lance+ and Lance+ Conical Connection in 2025. As the names suggest, some have a conical connection and some an internal hex connection. A conical connection is an arrangement in which the top part seats inside the implant in the shape of a cone; an internal hex is an older and more widespread arrangement in which it seats in a six-sided socket.

This variety has a practical consequence: knowing 'I have MIS' is not enough for a repair. A C1 with a conical connection and a Seven with an internal hex connection will not accept the same top part. Names typed into Google such as 'MIS C1' or 'MIS Seven' are exactly the line names that should be on the record; alongside them, your card should also show the platform, diameter, length and lot number. Top parts made by other companies to be compatible with MIS are also on the market; knowing which one was fitted is part of the record too.

The factual answer to the question of how well studied it is: there are clinical publications on PubMed under the MIS name, but most have a few years of follow-up and are of medium size. In a retrospective study carried out at three centres in Korea, 294 MIS Seven implants placed in 92 patients were followed for an average of 38 months, and cumulative survival was found to be 97.3 per cent. In a five-year follow-up of 60 C1 implants in 34 patients in Poland there were no losses, and bone loss around the conical-connection C1 was lower than around the internal hex implants of another brand it was compared with. In an average follow-up of 4.2 years of 100 Lance and Seven implants in 43 patients in Israel, no losses were seen either; however, one broken screw and two loose screws were recorded in the narrow-diameter implants.

These results need to be read with restraint. None of them is randomised. The Korean and Israeli studies are retrospective, meaning the records were examined after the event. The comparison in the Polish study covers two different brands and two different groups of patients; the difference in bone loss cannot be attributed to the connection type alone. Observational studies show an association; they do not prove cause and effect. Independent, large-scale MIS data covering more than ten years is more limited. This does not make MIS weak; it shows where the unknowns lie.

Even so, the brand is the smaller half of the question. Whether an implant will still be in your mouth years from now is decided, in this order, by planning, how firmly it seats in the bone, how the load is spread, control of smoking and diabetes, and regular maintenance. MIS's lines are conventional two-piece implants; the implant used in the protocol of fixed teeth in 72 hours with the Ihde method belongs to a different class: a one-piece corticobasal implant that anchors in the hard outer layer of the jaw.

The points below relate less to the brand name than to the conventional two-piece implant design and the practical advantages of a widely used system.

Six short questions. Each one has a clear answer; not getting an answer is information in itself.

1. 1

   Which MIS line, and which connection type?

   C1, V3, Seven, M4 or Lance+; conical or internal hex? The answer should be justified by the width, height and density of your bone.

2. 2

   Is a narrow-diameter implant being considered?

   When the bone is narrow, a narrow-diameter implant is an option. In the Israeli study, technical problems such as broken and loose screws were seen only in the narrow-diameter implants (three events in 50 implants); ask what precautions are being taken against this.

3. 3

   Can I see the product's ÜTS record?

   Medical devices put on the market in Turkey must be registered in the Product Tracking System (ÜTS). Whether a record exists can be checked using the unique number on the packaging label.

4. 4

   Is the top part original or a compatible part?

   Parts made by other companies to be compatible with MIS are also available. Knowing in advance which one will be used, and whether it will be put on record, makes repairs easier later on.

5. 5

   How does the supply of spare parts and screws work?

   When a screw comes loose or breaks, how long does the part take to arrive, and does the clinic keep it in stock? It should be possible to give the answer in days.

6. 6

   Will I be given my implant card?

   Brand, line, platform, diameter, length, lot number and the area where it was placed. The FDA also advises patients to ask for the brand and model of the implant used and to keep a record of it.

The points below determine how long an implant lasts more strongly than the brand name on it.

Some of the statements about this brand that circulate online are out of date, and some are incomplete.

In the first year these documents seem to be of no use. In the tenth year, in another city or another country, they are what proves most useful.

1. Get your implant card

   Saying MIS is not enough: it should also show the line name, connection type, platform, diameter, length and lot number. If you are not given one, asking for it is a normal request.

2. Ask for the details of the top part too

   Is it an original MIS part or a compatible one? The name of the screw and top part used directly shortens ordering parts in the future.

3. Keep the post-treatment X-ray

   It is the only document showing where your bone level was on the day of the procedure. If a loss is being discussed years later, this image is the point of comparison.

4. Keep a digital copy

   Keep photos of the card and the X-rays on your phone and in your email. When you move to another city or country, this may be the only thing you carry with you.

MIS is positioned as a more affordably priced range; but in a plan with several teeth, the unit price of the implant may not be the item that determines the total. The factors that determine the price are:

Unit price of the implant and importing

Because it is an imported system, shipping, customs, the importer's margin and the exchange rate are reflected in the price. The difference is real, but it may be a small part of the total.

Bridgework and clinical work

The prosthesis material, laboratory work and the top parts used take up a larger share than the implant itself in most plans. This is also where corners should not be cut.

Preparatory procedures

If extractions, a graft or a sinus procedure are needed, these are added as separate items, and in conventional two-piece plans they also extend the timescale.

Spare parts and repairs

With a widely used system, replacing a loose screw is a small job. A part that cannot be found can turn the same job into renewing the bridgework; this item does not appear on the bill, but it is the most expensive one.